Clemen 21 tablets

Estradiol tablets, cyproterone

• This medicine contains an estrogen and an anti-androgen.
• It is used to treat skin diseases such as acne, very oily skin and excessive hair growth in women of childbearing age. Due to its contraceptive properties, it should not be prescribed to you unless your doctor considers hormonal contraceptive therapy appropriate.
• You should not take this medicine unless your skin condition has not improved after using other anti-acne treatments, including topical treatments and antibiotics.
• If you are taking this medicine to treat the skin, you should not take any other hormonal contraceptives at the same time.
• When your skin condition clears up and you stop taking this medicine, you will need to go back to your original/preferred method of contraception.
• Treatment of skin diseases
Androgens are hormones that stimulate the growth of hair and the sebaceous glands in your skin. If you produce too much androgen, or if you are sensitive to the effect, your sebaceous glands may produce too much sebum. This can block the sebaceous glands, which can become inflamed and cause acne spots. It stops the effect of androgens on your skin and reduces the amount of androgens produced.
•Contraception
This medicine is a 21-day pill - you take 1 tablet a day for 21 days, followed by 7 days when you are not taking tablets.
This medication will not protect you from a sexually transmitted disease, such as chlamydia or HIV. Only a condom can help do this.
• This medication must be taken as directed to prevent pregnancy.
What you need to know before using estradiol, cyproterone

Do not use estradiol, cyproterone:

Tell your doctor if any of the following apply to you before you start using this medicine. Your doctor may then advise you to use a different treatment:
• If you are using another hormonal contraceptive
• If you are pregnant or may be pregnant
• If you are breast-feeding
• If you have or have ever had breast cancer
• If you have (or have ever had) a blood clot in your leg (thrombosis), lung (pulmonary embolism) or other part of your body.
• If you have (or have ever had) a disease that could indicate a future heart attack (eg angina pectoris causing severe chest pain) or a 'mini-stroke' (transient ischemic attack)
• If you have had (or have ever had) a heart attack or stroke.
• If you suffer from a condition that may increase the risk of a blood clot in the arteries. This applies to the following conditions:
o Diabetes affects blood vessels
o A severe increase in blood pressure
o High levels of fats in the blood (cholesterol or triglycerides)
• If you suffer from blood clotting problems (eg protein C deficiency)
• If you suffer (or have ever suffered from) migraine headaches with visual disturbances
• If you have ever had severe liver disease, tell your doctor that the results of the liver examination have not returned to normal
• If you have ever had liver tumors
• If you have or have been diagnosed with a meningioma (generally a benign tumor of the layer of tissue between the brain and the skull)
• If you are allergic (hypersensitive) to any of the ingredients in this medicine.

Cautions and precautions:
You should tell your doctor:
• If you or your family suffer from heart or circulatory problems, such as high blood pressure
• If you or your family suffer from blood clotting problems
• If you suffer from migraines
• If you are currently depressed or have done so in the past
• If you are overweight (obese)
• If you have a genetic disease called porphyria
• If you suffer from diabetes
• If you have inflammation of the pancreas (pancreatitis), or have a family history of high levels of fats in the blood (hypertriglyceridemia), you may be at risk of developing pancreatitis
• If you have brown spots on your face or body (chloasma)
• If you suffer from any disease that was aggravated during pregnancy or previous use of pills or this medicine

Other medicines and estradiol, cyproterone:
Tell your doctor about the medicines you are taking, and especially mention to your doctor if you are taking:
• If you are taking this medicine to treat the skin, do not take any other hormonal contraceptives at the same time.
• Medicines used to treat
o Epilepsy (such as primidone, phenytoin, barbiturates, carbamazepine, oxcarbazepine)
o Tuberculosis (eg, rifampicin).
o HIV infection and hepatitis C (so-called protease inhibitors and non-nucleoside reverse transcriptase inhibitors, such as ritonavir, nevirapine, efavirenz)
o Fungal infections (eg griseofulvin, ketoconazole)
O Arthritis and Arthritis (etoricoxib)
o High blood pressure in the blood vessels of the lungs (bosentan)
• Herbal remedy St. John's wort
• Medicines containing cyclosporine
The antiepileptic lamotrigine (this may increase the frequency of seizures)
Theophylline (used to treat breathing problems)
tizanidine (used to treat muscle pain and/or muscle spasms)

How to use estradiol, cyproterone:
Your doctor chose this medication as a treatment for acne or excessive hair growth on your face and body. However, this medicine also has a contraceptive effect, so it is important to follow the advice below if you are relying on this medicine to prevent pregnancy.
If you are only using this medication for acne or excessive hair growth, you can still follow this advice, but ask your doctor if you are unsure.

Duration of use:
Your doctor will tell you how long you need to keep taking this medicine.
How to take it:
Take this medication every day for 21 days
This medication comes in strips of 21 tablets, each marked with the day of the week.
• Take your pill at the same time every day.
• Start by taking a tablet marked with the correct day of the week.
• Follow the direction of the arrows on the tape. Take 1 tablet each day, until you have finished 21 tablets.
• Swallow each tablet whole, with water if needed. Do not chew the pill.
Then you have seven pill-free days
After you have taken all 21 tablets in the pack, you have seven days to not take a pill.

Possible side effects:
Stop using the product and seek immediate medical attention if:
• Swelling of the face, lips, tongue or throat, which may cause difficulty in breathing or swallowing
•Severe depression
• Signs of a blood clot

How to store estradiol, cyproterone:
• Keep all medicines out of the reach and sight of children.
• It is not allowed to store above 25°C.
• Do not use this medicine after the expiry date which is stated on the strip.
• Do not dispose of medicines down the drain or in the trash. Ask your pharmacist what to do with any medicines you do not want. This will help protect the environment