Co-Aprovel 300/12.5 mg 28 tablets

Co-Aprovel 300/12.5 mg 28 tablets:

Irbesartan/hydrochlorothiazide  300/12.5 mg.

A valid prescription must be presented upon receipt of the order.

What is irbesartan/hydrochlorothiazide and what is it used for:

• It is a combination of irbesartan, an angiotensin II receptor antagonist, and hydrochlorothiazide, a thiazide diuretic, indicated for high blood pressure:
• In patients who are not adequately controlled with monotherapy.
•  As initial treatment for patients who are likely to require multiple medications to achieve their blood pressure goal.

How to take irbesartan/hydrochlorothiazide: 

• Adults over 18 years of age and CrCl >30ml/min  The usual dose is one tablet daily.
• Irbesartan/hydrochlorothiazide tablet can be taken with or without food.
• It can be taken at any time of the day.
• It may be given with other antihypertensive agents.
• Do not break the tablet in half.
• Correct if the extent of depletion is known before starting the drug.

Do not take irbesartan/hydrochlorothiazide:

• Allergy to irbesartan or hydrochlorothiazide.
• Hypersensitivity to sulfonamide-derived drugs (eg sulfamethoxazole/trimethoprim, sulfasalazine).
• Anuria (not having enough urine).
• renal failure.
• Liver weakness.

Warnings and precautions:

• Talk to your doctor or pharmacist before taking irbesartan/hydrochlorothiazide:
• To monitor kidney function.
• To monitor potassium levels.
• If you suffer from vision problems such as myopia or glaucoma.
• If you have lupus.
• If you are at risk of dehydration.

Possible side effects: 

• fatigue.
• Dizziness.
• Myalgia.

Other medicines and irbesartan/hydrochlorothiazide:

• Tell your doctor or pharmacist about all the medications you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
• Increased risk of lithium toxicity when taken together
• Increased risk of kidney damage and reduced effects when taken with nonsteroidal anti-inflammatory drugs (NSAIDs) and COX-2 inhibitors (such as ibuprofen, ketoprofen, celecoxib)
• It is not recommended to use it with potassium supplements to avoid high blood potassium levels.

With hydrochlorothiazide only:

• Avoid cholestyramine and colestipol for maximum absorption
•  Adjust the dose of antidiabetics
• Monitor during use of alcohol, barbiturates, and narcotics due to potential hypotension