Janumet XR 50/1000 Mg 56 Tablets

Janumet XR 50/1000 Mg 56 Tablets

Why sitagliptin/metformin is used:

• This medication contains two different medications called sitagliptin and metformin.
  
• Sitagliptin belongs to a class of medications called DPP-4 inhibitors (dipeptidyl peptidase-4 inhibitors).
  
• Metformin belongs to a class of medications called biguanides.
  They work together to control blood sugar levels in adult patients with a type of diabetes called “type 2 diabetes.”
  
• This medication helps increase the levels of insulin your body produces after a meal and reduces the amount of sugar your body produces.

How to use sitagliptin/metformin:

• Always take this medication exactly as your doctor has told you to.
•  Consult your doctor or pharmacist if you are not sure.
  
• Take one tablet: twice daily orally
  
• With meals to reduce the chance of stomach upset.
  
• Your doctor may need to increase your dose to control your blood sugar.
  
• If you have impaired kidney function, your doctor may prescribe a lower dose.
  

Do not use sitagliptin/metformin:

• If you are allergic to sitagliptin, metformin, or any of the other ingredients of this medication.
  
• If you suffer from severe kidney failure.
  
• If you have uncontrolled diabetes, for example severe hyperglycaemia (high blood glucose), nausea, vomiting, diarrhoea, rapid weight loss, lactic acidosis or ketoacidosis.
  
• If you have a severe infection or are dehydrated.
  
• If you are having an X-ray where you will be injected with a dye. You will need to stop eating at the time of the scan for two or more days
• More after that as directed by your doctor, depending on how your kidneys are working.
  
• If you have recently had a heart attack or have serious blood circulation problems, such as 'shock' or breathing difficulties.
  
• If you have liver problems.
  
• If you are breastfeeding.

Warnings and precautions:

• Cases of inflammation of the pancreas (pancreatitis) have been reported in patients receiving this medicine.
  
• If you experience skin blisters, it may be a sign of a condition called bullous pemphigoid. Your doctor may ask you to stop this medication.
  Risk of lactic acidosis.

Talk to your doctor or pharmacist before taking:

• If you have or have ever had a disease of the pancreas (such as pancreatitis)
  
• If you have gallstones, alcoholism or very high levels of triglycerides (a type of fat) in your blood.
  
• If you have type 1 diabetes. This is sometimes called insulin-dependent diabetes.
  
• If you have or have ever had an allergic reaction to sitagliptin, metformin.
  
• If you take a sulfonylurea or insulin and diabetes medications, together.

Possible side effects:

Stop using the product and seek immediate medical attention if you experience:

• Tightness in the throat, swelling of the eyes, face, lips or tongue, or you feel faint or have difficulty breathing.
  
• Hives or itching of the face or body.

Other medicines and sitagliptin/metformin:

Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines. You may need more blood glucose tests and kidney function tests, or your doctor may need to adjust your dose. It is especially important to mention the following:

• Medicines (taken orally, inhaled or injected) used to treat diseases that involve inflammation, such as asthma and arthritis (corticosteroids).
  
• Medicines that increase urine production (diuretics).
• Medicines used to treat pain and inflammation (NSAIDs and COX-2 inhibitors, such as ibuprofen and celecoxib).
  
• Certain medicines to treat high blood pressure (ACE inhibitors and angiotensin II receptor antagonists).
  
• Specific medicines for the treatment of bronchial asthma (β-sympathomimetics).
  Iodinated contrast agents or alcohol-containing medications.
  
• Some medicines used to treat stomach problems such as cimetidine.
  
• Ranolazine, a medicine used to treat angina.
  
• Dolutegravir, a medicine used to treat HIV infection
  Vandtanib.