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Medications are used alone or with other medications to treat high blood pressure (hypertension).
Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems.
Methyldopa works by relaxing blood vessels so blood can flow more easily.
Take this medication by mouth with or without food as directed by your doctor.
Usually 2 to 4 times daily.
Start this medication or any new dose in the evening to reduce the risk of side effects.
Also, if your doses of this medication are not equal, take the larger dose at bedtime.
The dosage is based on your medical condition and response to treatment.
Use this medication regularly to get the most benefit from it. To help you remember, take it at the same time every day.
Continue taking this medication even if you feel well.
Most people with high blood pressure do not feel sick.
When used for a long time, this medication may not work as well and may require different doses or additional medication. Talk to your doctor if this medication stops working well (for example, if your blood pressure readings remain high or increase).
Dizziness, lightheadedness, drowsiness, headache, blocked nose, and weakness may occur as your body adjusts to the medication.
If any of these effects persist or worsen, tell your doctor or pharmacist promptly.
To reduce the risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position.
Remember that your doctor has prescribed this medication because they have judged that the benefit to you is greater than the risk of side effects.
Many people using this medication do not have serious side effects.
Tell your doctor right away if you have any serious side effects, including: fainting, muscle spasms/uncontrolled muscle movements, missed/stopped periods, decreased sexual desire/ability, or breast enlargement (in men).
Mental/mood changes (such as depression), symptoms of heart failure (such as shortness of breath, swelling of the ankles/feet, unusual tiredness, unusual/sudden weight gain).
Methyldopa rarely causes serious (rarely fatal) liver disease or a low red blood cell count (anemia). Tell your doctor right away if you develop any symptoms of liver disease or anemia, including unusual tiredness, fast heartbeat, unexplained fever, dark urine, persistent nausea, severe abdominal pain, and yellowing of the eyes/skin.
Before taking methyldopa, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems.
Talk to your pharmacist for more information.
Before using this medication, tell your doctor or pharmacist your medical history, especially if you experience dizziness or drowsiness. This drug may make you dizzy or drowsy. Alcohol or marijuana (cannabis) can make you more dizzy or drowsy. Do not drive, use machinery, or do anything that requires alertness until you can do so safely. Limit alcoholic beverages.
Talk to your doctor if you use marijuana (cannabis).
Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).
Older adults may be more sensitive to the side effects of this drug, especially dizziness (most likely when standing), fainting, or depression. Dizziness and fainting can increase the risk of falls.
Tell your doctor if you are pregnant before using this drug.
This drug passes into breast milk but is unlikely to harm a nursing infant.
Consult your doctor before breastfeeding.
This drug may increase your risk of serious side effects.
This document does not contain all possible drug interactions.
Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist.
Do not start, stop, or change the dosage of any medications without your doctor's approval. Some products that may interact with this drug include:
Iron products (such as ferrous sulfate, ferrous gluconate), lithium. Taking MAO inhibitors with this drug may cause a serious (possibly fatal) drug interaction. Avoid taking MAO inhibitors (isocarboxazid, linezolid, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, safinamide, selegiline, cetirizine, diphenhydramine), alprazolam, diazepam, zolpidem, muscle relaxants, and opioid pain relievers (such as codeine).
Check the labels on all your medications (such as allergy or cough-and-cold products) because they may contain ingredients that cause drowsiness.
Ask your pharmacist about using these products safely. Some products contain ingredients that can raise blood pressure. Tell your pharmacist about the products you use and ask how to use them safely.

