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Terbinafine is an allylamine belonging to a group of antifungal agents.
It is an antifungal against dermatophytes, molds, and some dimorphic fungi.
Terbinafine acts either as a fungicide or fungistatic depending on the type.
Terbinafine interferes with fungal ergosterol synthesis by inhibiting squalene epoxidase in the fungal cell membrane at an early stage.
This leads to a deficiency of ergosterol and accumulation of squalene inside the cells, resulting in fungal cell death.
Terbinafine is highly effective in fungal infections of the skin, hair, and nails caused by Trichophyton spp., Microsporum spp., and Epidermophyton.
It is also effective against cutaneous yeast infections, especially those caused by the genus Candida.
Topical terbinafine appears effective in pityriasis versicolor caused by Pityrosporum orbiculare.
Terbinafine tablets are necessary for hair or nail infections:
Usual oral dose:
Terbinafine 250 mg daily for 2 to 12 weeks depending on the infection.
Fungal nail infection (onychomycosis):
Terbinafine 250 mg once daily for 6 weeks.
Fungal nail infection (onychomycosis):
Terbinafine 250 mg once daily for 12 weeks.
Warnings and Precautions:
Before taking terbinafine, inform your doctor or pharmacist:
If you are allergic to it or have any other allergies.
Before using this medicine, inform your doctor or pharmacist about your medical history, especially: immune system problems, kidney diseases, liver diseases, lupus.
This medicine may make you more sensitive to sunlight.
Reduce your time in the sun.
Avoid tanning and sunlamps.
Use sunscreen and wear protective clothing when outdoors.
Tell your doctor immediately if you get sunburn or experience blisters/redness on your skin.
During pregnancy, this medicine should only be used when clearly needed.
Treatment of fungal nail infections can usually wait until after your baby is born.
Discuss the risks and benefits with your doctor.
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